Calorie restriction, a dietary regiment that has long been known to increase longevity, has recently been found to prevent autoimmune disease and slow down immune system aging. Calorie restriction with adequate nutrition improves immunity by increasing the T-cell population, lowering levels of the cytokine interleukin-6 (IL-6) and reducing levels of triiodothyronine (T3). The link between calorie restriction and longevity may be a consequence of more efficient immunity, which causes reduced susceptibility to disease.

Calorie restriction refers to the habit of limiting dietary energy intake (calories) to amounts 25-60 percent lower than control groups while following a diet that provides adequate lean protein and micronutrients (calorie restriction with optimal nutrition). The beneficial effects of calorie restriction were first demonstrated in 1934 by researchers at Cornell University who showed that laboratory rats that followed a reduced calorie diet had life spans twice as long as expected.

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